EVALUATION OF MALE SEX HORMONES AND TRACE ELEMENTS IN MALE TYPE 2 DIABETIC PATIENTS ATTENDING NNAMDI AZIKIWE UNIVERSITY TEACHING HOSPITAL DIABETIC CLINICS

AUTHOR: ONAH, CHRISTIAN EJIKE 

DEPARTMENT: MEDICAL LABORATORY SCIENCES

AFFILIATION: NNAMDI AZIKIWE UNIVERSITY, AWKA

There is accumulating evidence that the metabolism of several trace elements and male sex hormones are altered in type 2 diabetic mellitus and they may have specific role in the pathogenesis and progression of the disease. The aims of this study are to investigate the levels of trace elements and male sex hormones in serum of patients with type 2 diabetes mellitus and to find out if there is any association between trace elements and male sex hormones in these diabetic subjects. One hundred and twenty five male type 2 diabetic subjects and 50 apparently healthy non-diabetic individuals were recruited into this study. After overnight fasting, blood was collected from each subject and fasting blood glucose, serum trace elements and serum male sex hormones were measured by glucose oxidase method, atomic absorption spectrophotometric method and Enzyme linked immunosorbent assay methods respectively. The results were subjected to statistical analysis (SPSS ver.16) and the comparism made using Students’t-test and Pearson correlation analysis and the level of significance taken at Pvalue <0.05. The mean value of Zn, Mn, Se, and Cr were significantly lower in serum of diabetic patients when compared with the control (Zn: 898.7±131.0μg/l; Mn: 0.30±0.06μg/l; Se: 51.3±11.1μg/l; Cr: 0.04±0.03μg/l) vs. (Zn: 1007.3±85.2μg/l; Mn: 0.50±0.07μg/l; Se: 62.1±11.1μg/l; Cr: 0.06±0.01μg/l; P<0.05). Also, the mean value of FSH and prolactin were significantly higher in diabetics subjects when compared with the non-diabetic controls (FSH: 6.3±3.8 μIU/ml; prolactin: 21.0±6.1 ng/ml) vs. (FSH: 4.8±1.8 μIU/ml; Prolactin: 17.7±4.5 ng/ml; P<0.05). However, the mean level of testosterone was significantly lower in diabetics than in controls (3.9±1.9 ng/ml) vs. (5.1±1.7 ng/ml; P<0.05), but there was no significant difference in the concentration of LH in diabetics and control subjects (4.1±4.0 μIU/ml) vs. (2.9±1.6). The mean Fasting blood Glucose in diabetic subjects was significantly higher when compared with the healthy controls (7.9±3.7 mmol/l) vs. (4.6±0.4 mmol/l; P<0.05). However, the mean level of Body Mass Index (BMI) of the type 2 diabetic subjects did not show any significant difference when compared with the healthy controls (25.5±2.5 Kg/m2) vs. (25.1±1.6 Kg/m2). The trace elements showed a positive correlation with testosterone in diabetic subjects (Zn r = 0.359, Se r = 0.443 , Mn r = 0.350, P<0.05). This study showed that decreased levels of testosterone and trace elements are found in type 2 diabetic patients and there is a positive correlation between low testosterone level and low trace elements level in diabetic subjects. In addition, these trace elements (Zn, Mn, and Se) are components of antioxidant and there levels in these diabetic patients suggest a depression in antioxidant status and this may further increase the severity of this disease.

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