OVARIAN RESERVE FUNCTION AND ANOVULATION IN UNMARRIED WOMEN OF CHILD-BEARING AGE IN ANAMBRA STATE.

AUTHOR: ANYADIKE, NORAH NWADIOGO 

DEPARTMENT: CHEMICAL PATHOLOGY

AFFILIATION: NNAMDI AZIKIWE UNIVERSITY, AWKA

The study evaluated ovarian reserve function and ovulatory status of unmarried females of child-bearing age in Nnewi and Ihiala towns of Anambra state. Two hundred and thirty female subjects aged 18-30 years participated in the study and were divided into unmarried females (n=155) and married females (n=75). Blood samples were collected from the participants at day 3-4 and 21-23 of menstrual cycle for hormonal profile assays. The concentrations of Follicle Stimulating Hormone (FSH), Luteinizing Hormone (LH), Prolactin (Prl), Progesterone (Prog.), Oestrogen (E2), Testosterone (Testo) and Thyroid Stimulating Hormone (TSH) were measured using Enzyme Linked Immunosorbent Assay (ELISA) method. The ovarian reserve function (ORF) was evaluated based on FSH and E2 values of day 3-4 of menstrual cycle while the ovulatory status was evaluated based on Progesterone values of day 21-23 of menstrual cycle. The day 3-4 hormonal profile analyses results showed: the mean(±SD) FSH values in participants with normal ovarian reserve function (NORF) 132 (85.2%), hypo ovarian reserve function (HORF) 13 (8.4%) and poor ovarian reserve function (PORF) 10 (6.5%) (P<0.05). Distribution of unmarried and married participants using their ORF and ovulatory status based on day 21-23 Progesterone showed that of the 29 (12.6%) HORF, 12 (5.2%) were anovulatory and 17 (7.4%) were ovulatory; out of 87 (37.8%) NORF, 42 (18.3%) were anovulatory and 45 (19.6%) were ovulatory; out of 39 (17.0%) PORF, 21 (9.15) were anovulatory and 18 (7.8%) were ovulatory. The married controls 75 (32.6%) are all ovulatory (P<0.05). Mean(±SD) of day 3-4 hormonal profiles of participants showed significant differences among the groups in FSH, LH, Prl, E2 and Testo. (P<0.05). Prog. and TSH did not show significant differences. Also, Mean±(SD) of day 21-23 hormonal profiles of participants showed significant differences in FSH, Prl, Testo and TSH (P<0.05). LH, Prog. and E2 did not show significant differences.

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