AUTHOR: EZEAGWUNA DOROTHY A.
DEPARTMENT: PARASITOLOGY AND ENTOMOLOGY
AFFILIATION: NNAMDI AZIKIWE UNIVERSITY, AWKA
A study on the efficacy of artesunate in the treatment of urinary schistosomiasis at Umuikwu- Anam community, Anambra West Local Government area was carried out between November 2008 and June 2009. Urine samples from 471 primary school children were examined for ova of Schistosoma haematobium . Using filtration method, S. haematobium ova was recorded in the urine samples of 72(15.3%) pupils. The prevalence of 34.4% and 28.2% were recorded in two primary schools with an overall egg output of 7.63 eggs/10mls urine (geometric mean). The prevalence was significantly higher in the males (18.2%) than in the females (11.3%) and among the 11-13 years age group (25.6%; p<0.05). The intensity was also significantly higher among the males (48) and 5-10 years age group (39). Infected pupils who reported for treatment were divided into three groups ;oral doses of praziquantel (40mg/kg-single dose), artesunate (4mg/kg/day) once a day for 3 days and a combination of praziquantel and artesunate respectively. When the treated children were examined after 2weeks, praziquantel had the highest egg reduction rate of 92.63%, combined therapy of artesunate and praziquantel had egg reduction rate of 90.22% while artesunate had a 72.86% egg reduction rate. There was significant difference in the treatment regimen and all the treatments were significantly effective (P<0.50). All the treatment regimen were well tolerated.
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Tags: Artemether, Artemisinin, Artesunate, Combination Therapy for Schistosomiasis, Life Cycle of Schistosoma haematobium, Oxamniquine, Parasitology and Entomology Thesis 2010, Praziquantel, Prevalaence of Schistosomiasis, Schistosoma haematobium, Schistosoma intercalatum, Schistosoma japonicum, Schistosoma mansoni, Schistosoma mekongi, Schistosomiasis, Treatment of Urinary Schistosomiasis, Urinary schistosomiasis