ANTI-HYPERGLYCEMIC EFFECT OF Ipomea batatas TUBER DIET IN ALLOXAN-INDUCED DIABETIC WISTAR ALBINO RATS.

AUTHOR: AJOKU, KELECHI LEO DEPARTMENT: APPLIED BIOCHEMISTRY AFFILIATION: BIOSCIENCES Two similarly compounded meals containing 65% of Ipomea batatas tuber flour( test diet) and 65% maize grain flour (comparative test diet) as their carbohydrate source, as well as a commercial rat chow (control diet) were fed ad libitum to normal and alloxaninduced diabetic rats as their only daily meals for six (6) weeks and their effects on fasting blood glucose (FBG) level, serum alanine aminotransferase (ALT) activity, serum aspartate aminotransferase (AST) activity, serum alkaline phosphatase (ALP) activity and packed cell volume (PCV) were evaluated. Results obtained showed that the Ipomea batatas tuber diet significantly (p0.05), the test diet also effected a slight decrease in the FBG level of the normal animals when compared with the other normoglycemic groups respectively fed with maize and control diets. No significant (p>0.05) decreasing effect on the FBG levels were recorded in both diabetic and normal rats fed with the maize and control diets. Also, the test diet showed no significant (p>0.05) effect on ALT and AST activities, but elicited a significant (p<0.05) increased ALP activity in the diabetic animals, relative to those of the normoglycemic control group. Both the maize and control diets produced significant (p<0.05) increases in serum ALT, AST and ALP activities in the diabetic rats when compared with those of the normoglycemic control group. However, no significant differences were observed in the PCV levels of both the diabetic and normoglycemic animals when compared with that of the normal control animals. Above all, high mortalities were recorded in the diabetic groups fed with the maize diet and commercial diet while no such occurrence was observed with the Ipomea batatas diet. These imply that Ipomea batatas tuber is a potent anti-hyperglycemic carbohydrate food, which could be employed in the treatment and management of diabetes mellitus.

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