HAEMATOCRIT, RED CELL INDICES, HAEMORHEOLOGY AND LIPID PROFILE OF INDIVIDUALS LIVING WITH HIV/AIDS AND THOSE ON ANTI-RETROVIRAL THERAPY IN DELTA STATE, NIGERIA.

AUTHOR: OSAKUE, IKPONMWOSA STANLEY

DEPARTMENT: MEDICAL LABORATORY SCIENCE

AFFILIATION: NNAMDI AZIKIWE UNIVERSITY, AWKA

This work was designed to study the effect of HIV and Anti-retroviral therapy on some haematological, haemorheological and lipid profile among HIV-positive on ART (n=85), those not on ART (n=90) and apparently healthy individuals as control (n=78). Subjects were of both sexes within the age range of 16-58years. Informed consent was obtained verbally from all participants. Ethical approval was obtained from the ethical committee of Delta State Hospital Management board. CD₄+ count by PartecCyflow, Haematocrit, mean corpuscular volume, mean corpuscular haemoglobin, mean corpuscular haemoglobin concentration, red cell distribution width by Dirui haematology auto-analyser, whole blood and plasma viscosity using a modified method by Reid and Ugwu, plasma fibrinogen using the method by miller et al, total cholesterol, high density lipoprotein-cholesterol and triglyceride were evaluated using routine enzymatic colorimetric kits while low and very low density lipoprotein were extrapolated using Friedewald’s formula. SPSS version 21 was used for statistical data analysis.Whole blood and plasma viscosity, plasma fibrinogen, total cholesterol (T-chol), triglyceride (TG), low density lipoprotein (LDL)-cholesterol, very low density lipoprotein (VLDL)-cholesterol were significantly higher in HIV-positive subjects on ART and those not on ART compared to the controls (p<0.05). While Haematocrit (HCT), CD₄+ count, MCH, MCHC were significantly lower in HIV-positive subjects on ART and those not on ART compared to the controls (p<0.05). No significant difference was observed in the high density lipoprotein (HDL)-cholesterol in these groups (p>0.05). All variables with known impact on blood viscosity were altered in both HIV-positive on anti-retroviral therapy (ART) and those not on ART. Inappropriate regulation of red cell formation, increased serum cholesterol, triglyceride and plasma fibrinogen may be as a result of HIV infection which could aggravated with ART.

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