SERUM PROTEINS, IMMUNOGLOGULINS AND SOME HAEMATOLOGICAL PARAMETERS IN PATIENTS WITH PULMONARY TUBERCULOSIS IN NNAMDI AZIKIWE UNIVERSITY TEACHING HOSPITAL , NNEWI

AUTHOR:UMEH, OKECHUKWU ELIJAH

DEPARTMENT: MEDICAL LABORATORY SCIENCE  

AFFILIATION: NNAMDI AZIKIWE UNIVERSITY, AWKA

Pulmonary tuberculosis (PTB) is a common disease in developing countries with resultant complex haematological and biochemical picture that may either confuse in diagnosis or could be used in combination to aid diagnosis . This study was aimed at looking at the total protein, immunoglobulins (IgG and IgM) and some haematological parameters in patient’s with PTB. A total of 220 PTB patients aged between 18-60 years were recruited for this study. 100 were in their pretreatment stage (group B) and 40 each in their 2 months treatment stage (group C), 4 months treatment stage (group D), and 6 months treatment stage (group E) respectively. 80 non PTB subjects served as control (group A). The study subjects were tested for total protein, albumin and globulin using biuret method; IgG and IgM using turbidimetric method; FBC and ESR using routine manual method after obtaining informed consent. ANOVA and student’s t-test were used for the statistical analysis. The platelet count (x109/L) in group B when compared with control group A, group C, D and E was significantly higher (p<0.05) . TWBC (x109/L) in group B when compared with control group A, group C, D and E was significantly higher (p<0.05) . The value of the ANC (x109/L) was significantly higher in group B when compared with control group A, group C, D and E (p<0.05) .The value of the ALC (x109/L) was significantly lower in group B when compared with control group A, group C, D and E (p<0.05). The total protein (g/dl); Globulin (g/dl); IgG (mg/dl) and IgM (mg/dl) in group B when compared with control group A, group C, D and E were significantly higher ( p<0.05) respectively in each case. Albumin (g/dl) in group B when compared with control group A, group C, D and E was significantly lower (p<0.05) .Platelet count was significantly higher in females when compared with male subjects. Conclusively, the results of this study indicates increased total protein and globulin level and reduced albumin level; increase IgG and IgM level; decrease Hb and PCV; increase ESR, total leucocytes count, absolute neutrophil count, platelet count and decrease lymphocyte count in patients with pulmonary tuberculosis

TO VIEW THE FULL CONTENT OF THIS DOCUMENT, PLEASE VISIT THE UNIZIK LIBRARY WEBSITE USING THIS LINK,http://naulibrary.org/dglibrary/admin/book_directory/Thesis/11698.pdf

Advertisements

Tags: , , , , , , , , ,

Leave a Reply

Fill in your details below or click an icon to log in:

WordPress.com Logo

You are commenting using your WordPress.com account. Log Out / Change )

Twitter picture

You are commenting using your Twitter account. Log Out / Change )

Facebook photo

You are commenting using your Facebook account. Log Out / Change )

Google+ photo

You are commenting using your Google+ account. Log Out / Change )

Connecting to %s


%d bloggers like this: