The Effects of Metoclopramide and Bromocriptine on Immune-related Leucocyte of Dogs

Author: Obinwogu Donatus Lotanna
Department: Human Physiology
Affiliation: Nnamdi Azikiwe University Awka

The relationship between the prolactin hormone and immunity has been variously established. In the present study, Metopclopramide and Bromocriptine were used to induce hyperprolactinaemia and hypoprolactinaemia, respectively, to evaluate the effects on immune related leucocytes of dogs. Thirty male Mongrel dogs weighing between 5kg and 10kg were used for the study. The experiment lasted for 28 days. The dogs were acclimatized for the first 14 days after which metopclopramide and bromocriptine were administered. The animals were split into ten dogs per group. Group 1 served as the control and was given distilled water. Group 2 was administered 20mg metoclopramide injection intramuscularly per body weight and served as the hyperprolactinaemic group. Group 3 was administered with an oral daily dose of 5mg of bromocriptine per body weight which served as hypopolactinaemic group. The result of the study showed that there was a statistically significant increase in prolactin levels (10.66±0.92ng/ml) of the hyperprolactinaemic group compared to the control group (9.95±0.56), (P<0.05). Also, the mean total white blood cell count of the hyperprolactinaemic group (524.00±203.63) showed a statistically significant difference (P=0.02) when compared to the control (345±82.41). Comparison between the total white blood cell count of the hyperprolactinaemic group (524.00±203.63) and the hypoprolactinaemic group (321.80±124.78) also showed a statistical significance (P=0.01). The finding of this study suggests that hyperprolactinaemia might be associated with an increase in leucocyte profile.

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