EVALUATION OF EFFECTS OF BOILED FLUTED PUMPKIN (Telfairia occidentalis) SEEDS ON SERUM LIPID PROFILE, ATHEROGENIC INDICES AND IMMUNOGLOBULIN PROFILE OF MALE ALBINO WISTAR RATS

Author: Ude Tochukwu
Department: Medical Laboratory
Affiliation: Nnamdi Azikiwe University Awka

The study is aimed at investigating the effect of Telfairia occidentalis seed diet on the serum lipid profile, immmunoglobulins and atherogenic indices of adult male albino wistar rats. This is an animal experimental control study. A total of (N) 40 male albino wistar rats weighing 120-136 g with the age range of 8 to 10 weeks were divided into four groups (n) of 10 rats each and designated A to D. The groups were given the dose of 0.0, 12.5, 37.5 and 75g of T. occidentalis per body weight respectively for 28 days. Blood samples were taken from the animals and subjected to various biochemical analysis. Serum concentrations of lipids and immune-globulins were estimated using the colorimetric and immune-turbidometric methods, respectively. Data were analysed using SPSS software application (version 16.0) and expressed as Mean ± Standard deviation. The results revealed significant decreases in total cholesterol (2.00±0.24 to 1.76±0.24), LDL-C (0.34±0.17 to 0.27±0.05), VLDL, (0.20±0.05 to 0.14±0.05), and NHDL-C (0.74±0.13 to 0.23±0.12) while significant increases were observed in IgG (1.08±0.35 to 2.10±0.43), HDL (1.26±0.12 to 1.53±0.14) and body weight (33.39±6.26 to 91.50±5.23) when compared with the control group (p0.05). The diet supplementation also led to significant decreases in atherogenic indices; CRR (1.53±0.15 to 1.14 ± 0.07), AC (0.71±0.40 to 0.14±0.07) and AIP (-0.05±0.06 to -0.31±0.12) when compared to the control group (p<0.05). These results indicate a likely potential dose dependent immunomodulative and cardio-protective mechanism of the seeds of T. occidentalis against the possible development of atherosclerosis and coronary heart disease.

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