Author: Udo John Ndubuisi
Department: Chemical Pathology
Affiliation: Nnamdi Azikiwe University Awka

Pre-eclampsia is a pregnancy specific condition of unknown cause that increases maternal and infant mortality. The aim of this study was to evaluate the serum lipid profile, atherogenic index of plasma (AIP), high sensitivity C-reactive protein (hs-CRP) and sex hormone binding globulin (SHBG) in preeclampsia. During their third trimester (mean gestational age 33weeks), 35 Pre-eclamptic women (mean age 30.91 ± 5.92), 35 non pre-eclamptic women (mean age 28.89 ± 4.28) and 23 non-pregnant women (mean age 30.48 ± 7.05) as a second control group underwent basic biochemical analysis of lipid profile (LDL-C, TG, TC and HDL-C), serum hs-CRP and SHBG. Results of the clinical characteristics of the three groups showed that the pre-eclamptic group had a significantly higher BMI, diastolic and systolic blood pressure (P < 0.05) while the mean arterial blood pressure was also statistically significantly increased within the three groups (p< 0.001). Biochemical analysis showed that Pre-eclamptic women had a significantly lower mean serum SHBG level compared to the non pre-eclamptic group (P ═ 0.038). Group with pre-eclampsia showed a significant lower mean serum HDLC level compared with non pre-eclamptic group (1.10 ± 0.12mmol/L vs 1.26 ± 0.15mmol/L; P < 0.001), the atherogenic index of plasma was also statistically significantly increased among the three groups (p < 0.001). There was a significant increase in mean serum hs-CRP in pre-eclampsia when compared with the non pre-eclamptic women (8.57 ± 2.68mg/L vs 6.46 ± 2.45mg/L; P ═ 0.001). Also there was a higher mean serum triglyceride level in pre-eclampsia when compared to the non pre-eclamptic group (P < 0.001). Moreover, there was and a higher serum total cholesterol value (P < 0.001). However there was no statistically significant difference in the LDL-C levels (P ═ 0.492) between the group of pre-eclamptic women and the non pre-eclamptic women. But when comparing the three groups, there was a statistically significant difference in all the biochemical parameters evaluated apart from the LDL-C levels which was statistically similar in the three groups (P ═ 0.235). The results of this study indicate evidence of possible deranged lipid metabolism, an increased risk for CVD and generalized inflammation marked by an increase in mean serum hs-CRP levels and reduced SHBG levels in pregnancy.

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